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COMMUNICATIONS TO THE EDITOR
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4911-4914
| Mutational Evidence for a Common  Antagonist Binding Pocket in the Wild-Type and Mutant  [K303E] Opioid Receptors
Robert M. Jones,
Siv A. Hjorth,
Thue W. Schwartz, and
Philip S. Portoghese
[Full Article -
PDF] |
4915-4917
| Dual D2-Receptor and  2-Adrenoceptor Agonists for the Treatment of Airway Diseases. 1. Discovery and Biological Evaluation of Some 7-(2-Aminoethyl)- 4-hydroxybenzothiazol-2(3H)-one Analogues
Roger V. Bonnert,
Roger C. Brown,
David Chapman,
David R. Cheshire,
John Dixon,
Francis Ince,
Elizabeth C. Kinchin,
Amanda J. Lyons,
Andrew M. Davis,
Catherine Hallam,
Stephen T. Harper,
John F. Unitt,
Iain G. Dougall,
Dale M. Jackson,
Kenneth McKechnie,
Alan Young, and
Wilfred T. Simpson
[Full Article -
PDF] |
ARTICLES
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4918-4926
| Structure-Activity Relationships for Antiplasmodial Activity among 7-Substituted 4-Aminoquinolines
Dibyendu De,
Frances M. Krogstad,
Larry D. Byers, and
Donald J. Krogstad
[Full Article -
PDF] |
4927-4932
| Polyanion Inhibitors of HIV and Other Viruses. 7. Polyanionic Compounds and Polyzwitterionic Compounds Derived from Cyclodextrins as Inhibitors of HIV Transmission
Alain Leydet,
Céline Moullet,
Jean Pierre Roque,
Myriam Witvrouw,
Christophe Pannecouque,
Graciela Andrei,
Robert Snoeck,
Johan Neyts,
Dominique Schols, and
Erik De Clercq
[Full Article -
PDF] |
4933-4938
| N-n-Propyl-Substituted 3-(Dimethylphenyl)piperidines Display Novel Discriminative Properties between Dopamine Receptor Subtypes: Synthesis and Receptor Binding Studies
Luigi Cervetto,
Gian Carlo Demontis,
Gino Giannaccini,
Biancamaria Longoni,
Bruno Macchia,
Marco Macchia,
Adriano Martinelli, and
Elisabetta Orlandini
[Full Article -
PDF] |
4939-4949
| Correlation of Human Jejunal Permeability (in Vivo) of Drugs with Experimentally and Theoretically Derived Parameters. A Multivariate Data Analysis Approach
Susanne Winiwarter,
Nicholas M. Bonham,
Fredrik Ax,
Anders Hallberg,
Hans Lennernäs, and
Anders Karlén
[Full Article -
PDF] |
4950-4957
| Characterization of Novel N,N'-Disubstituted Piperazines as  Receptor Ligands
Ying Zhang,
Wanda Williams,
Cheryl Torrence-Campbell,
Wayne D. Bowen, and
Kenner C. Rice
[Full Article -
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4958-4964
| Antiviral Oligo- and Polyribonucleotides Containing Selected Triazolo[2,3-a]purines
Mayoka G. Tutonda,
Robert W. Buckheit, Jr.,
Vijai K. Agrawal, and
Arthur D. Broom
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4965-4972
| Methoxy-Substituted 3-Formyl-2-phenylindoles Inhibit Tubulin Polymerization
Robert Gastpar,
Michael Goldbrunner,
Doris Marko, and
Erwin von Angerer
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4973-4982
| Synthesis and Biological Properties of New 2-Alkyl- and 2-Aryl-3-(substituted phenyl)tropane Derivatives: Stereochemical Effect of C-3 on Affinity and Selectivity for Neuronal Dopamine and Serotonin Transporters
Alan P. Kozikowski,
Gian Luca Araldi,
K. R. C. Prakash,
Mei Zhang, and
Kenneth M. Johnson
[Full Article -
PDF] |
4983-4994
| Tetrahydro-isoquinoline-Based Factor Xa Inhibitors
Ralf Kucznierz,
Frank Grams,
Herbert Leinert,
Klaus Marzenell,
Richard A. Engh, and
Wolfgang von der Saal
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PDF] |
4995-5001
| Synthesis and Serotonin Receptor Affinities of a Series of trans-2-(Indol-3-yl)cyclopropylamine Derivatives
Suwanna Vangveravong,
Arthi Kanthasamy,
Virginia L. Lucaites,
David L. Nelson, and
David E. Nichols
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PDF] |
5002-5011
| Constrained Corticotropin-Releasing Factor (CRF) Agonists and Antagonists with i-(i+3) Glu-Xaa-DXbb-Lys Bridges
Steven C. Koerber,
Jozsef Gulyas,
Sabine L. Lahrichi,
Anne Corrigan,
A. Grey Craig,
Catherine Rivier,
Wylie Vale, and
Jean Rivier
[Full Article -
PDF] |
5012-5019
| Astressin Analogues (Corticotropin-Releasing Factor Antagonists) with Extended Duration of Action in the Rat
Jean Rivier,
Jozsef Gulyas,
Anne Corrigan,
Vicente Martinez,
A. Grey Craig,
Yvette Taché,
Wylie Vale, and
Catherine Rivier
[Full Article -
PDF] |
5020-5036
| N-(2-Benzoylphenyl)-L-tyrosine PPAR Agonists. 1. Discovery of a Novel Series of Potent Antihyperglycemic and Antihyperlipidemic Agents
Brad R. Henke,
Steven G. Blanchard,
Marcus F. Brackeen,
Kathleen K. Brown,
Jeff E. Cobb,
Jon L. Collins,
W. Wallace Harrington, Jr.,
Mir A. Hashim,
Emily A. Hull-Ryde,
Istvan Kaldor,
Steven A. Kliewer,
Debra H. Lake,
Lisa M. Leesnitzer,
Jürgen M. Lehmann,
James M. Lenhard,
Lisa A. Orband-Miller,
John F. Miller,
Robert A. Mook, Jr.,
Stewart A. Noble,
William Oliver, Jr.,
Derek J. Parks,
Kelli D. Plunket,
Jerzy R. Szewczyk, and
Timothy M. Willson
[Full Article -
PDF] |
5037-5054
| N-(2-Benzoylphenyl)-L-tyrosine PPAR Agonists. 2. Structure-Activity Relationship and Optimization of the Phenyl Alkyl Ether Moiety
Jon L. Collins,
Steven G. Blanchard,
G. Evan Boswell,
Paul S. Charifson,
Jeff E. Cobb,
Brad R. Henke,
Emily A. Hull-Ryde,
Wieslaw M. Kazmierski,
Debra H. Lake,
Lisa M. Leesnitzer,
Jürgen Lehmann,
James M. Lenhard,
Lisa A. Orband-Miller,
Yolanda Gray-Nunez,
Derek J. Parks,
Kelli D. Plunkett, and
Wei-Qin Tong
[Full Article - PDF] |
5055-5069
| N-(2-Benzoylphenyl)-L-tyrosine PPAR Agonists. 3. Structure-Activity Relationship and Optimization of the N-Aryl Substituent
Jeff E. Cobb,
Steven G. Blanchard,
Evan G. Boswell,
Kathleen K. Brown,
Paul S. Charifson,
Joel P. Cooper,
Jon L. Collins,
Milana Dezube,
Brad R. Henke,
Emily A. Hull-Ryde,
Debra H. Lake,
James M. Lenhard,
William Oliver, Jr.,
Jeffery Oplinger,
Mila Pentti,
Derek J. Parks,
Kelli D. Plunket,
and
Wei-Qin Tong
[Full Article - PDF] |
5070-5083
| Design and Synthesis of a Series of 6-Substituted-2-pyridinylmethylamine Derivatives as Novel, High-Affinity, Selective Agonists at 5-HT1A Receptors
Bernard Vacher,
Bernard Bonnaud,
Philippe Funes,
Nathalie Jubault,
Wouter Koek,
Marie-Bernadette Assié, and
Cristina Cosi
[Full Article - PDF] |
5084-5093
| Spiperone: Influence of Spiro Ring Substituents on 5-HT2A Serotonin Receptor Binding
Kamel A. Metwally,
Malgorzata Dukat,
Christina T. Egan,
Carol Smith,
Ann DuPre,
Colleen B. Gauthier,
Katharine Herrick-Davis,
Milt Teitler, and
Richard A. Glennon
[Full Article - PDF] |
5094-5107
| Nucleosides and Nucleotides. 180. Synthesis and Antitumor Activity of Nucleosides That Have a Hydroxylamino Group Instead of a Hydroxyl Group at the 2'- or 3'-Position of the Sugar Moiety
Akira Ogawa,
Motohiro Tanaka,
Takuma Sasaki, and
Akira Matsuda
[Full Article - PDF] |
NOTES
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5108-5112
| Synthesis of Imidazo[1,2-a]pyridines as Antiviral Agents
Alain Gueiffier,
Sylvie Mavel,
Mohammed Lhassani,
Ahmed Elhakmaoui,
Robert Snoeck,
Graciela Andrei,
Olivier Chavignon,
Jean-Claude Teulade,
Myriam Witvrouw,
Jan Balzarini,
Erik De Clercq, and
Jean-Pierre Chapat
[Full Article - PDF] |
5113-5117
| Stereoisomers of Cyclic Urea HIV-1 Protease Inhibitors: Synthesis and Binding Affinities
Robert F. Kaltenbach III,
David A. Nugiel,
Patrick Y. S. Lam,
Ronald M. Klabe, and
Steven P. Seitz
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BOOK REVIEWS
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5118-5118
| The Molecular and Supramolecular Chemistry of Carbohydrates By Serge David. Oxford University Press, New York. 1998. vii + 320 pp. 15.5 × 23 cm. ISBN 0-19-850046-7. $45.00.
Daniel E. Levy
[Full Article - PDF] |